Optimization of Gelling Agents and Emulsifiers in Emulgel Bases, and Physical Evaluation of Emulgel containing Sepabang (Melastoma malabathricum L.) Leaves Extract
DOI:
https://doi.org/10.30872/j.trop.pharm.chem.v5i2.190Keywords:
Emulgel, Carbopol, HPMC, Emulsifier, SepabangAbstract
Sepabang (Melastoma malabathricumshot L.) leaf contains a group of phenolic compounds and has a very strong antioxidant activity so it is potentially to be developed in the form of pharmaceutical preparations. The purpose of this research is to optimize and formulate an emulgel containing Sepabang leaf extract that physically stable. Emulgel preparations are formulated using carbopol and hydroxyprophylmethylcellulose as gelling agents and Tween 60 – Span 60 and combination of triethanolamine and stearic acid as emulsifiers, with a concentration of methanol extract of Sepabang leaves of 0.25%. Physical characteristics of emulgel preparations include pH value, viscosity determination, and spreadability test evaluated at room temperature for 4 weeks. The physical stability test is done by the Freeze Thaw method for 6 cycles, of which 1 cycle consists of 48 hours at 4°C and 48 hours at 40°C. The results showed that the Sepabang emulgel that meet physical characteristic and stability parameters are F1 with HPMC as gelling agents and Tween 60-Span 60 3% as emulsifiers.
References
[1] Sardjono, Mustopa A., 2015. Riset Khusus Eksplorasi Pengetahuan Lokal Elnomedisindan Tumbuhan Obat berbasis Komunitas di Indonesia, Kementerian Kesehatan RI, Jakarta.
[2] Joffry, S.M., 2012. Melastoma malabathricum L. Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review, Evidence-Based Complementary and Alternative Medicine, Hindawari Publishing Corporation, Evidence-Based Complenetary and Alternative Medicine, Volume 2012, Article ID 258434, Page 1-48
[3] Mita, N., Arifuddin, M., Ardana, M., Priastomo, M., Farida, S., 2017. Determination of Extract Quality Parameters of Sepabang (Melastoma malabathricum L.) Leaves from Dayak Bahau and Abai Ethnics in Borneo and Its Antibacterial and Antifungal Activities, 3rd International Seminar on Natural Product, April 1st 2017, Makassar, Indonesia
[4] Thakur, R., Jain, N., Pathak, R., Sandhu, S.S.. 2011. Practices in Wound Healing Studies of Plants, Review Article Evidence-Based Complementary and Alternative Medicine, p. 1-15
[5] Prasad, Mahapatra Annada, et al, 2012. Formulation and Evaluation of Cream Prepared From Croton Sparsiflorus Morong And Their Wound Healing Activity. International Journal Of Research In.
[6] Handayani, M., Mita, N., & Ibrahim, A., 2015. Formulasi dan Optimasi Basis Emulgel Carbopol 940 dan Trietanolamin dengan Berbagai Variasi Konsentrasi. Proceeding of Mulawarman Pharmaceuticals Conferences, 1(1), 53-60. https://doi.org/10.25026/mpc.v1i1.8
[7] Pramita R, I., Fitriani, V. Y., Mita, N., & Ramadhan, A. M., 2017. Pegaruh Konsentrasi HPMC (Hidroxy Propyl Methyl Cellulose) Sebagai Gelling Agent dengan Kombinasi Humektan Terhadap Karakteristik Fisik Basis Gel. Proceeding of Mulawarman Pharmaceuticals Conferences, 5(1), 139-148. https://doi.org/10.25026/mpc.v5i1.230
[8] Mita, N., 2015. Formulasi Krim dari Kulit Buah Kakao (Theobroma cacao L.) Berkhasiat Antioksidan, Journal of Tropical Pharmacy and Chemistry, 3(1), 12-21. https://doi.org/10.25026/jtpc.v3i1.83
[9] Anggraini, S., Mita, N., & Ibrahim, A., 2015. Formulasi Krim Antioksidan Daun Cempedak (Artocarpus champeden Spreng), Proceeding of Mulawarman Pharmaceuticals Conferences, 2(1), 8-15. https://doi.org/10.25026/mpc.v2i1.32
[10] Mita, N., Tarini D., S., & Damayanti, S. (2015). Evaluasi Formula Krim Minyak Biji Delima (Punica granatum L.) dan Uji Aktivitas Antioksidan dengan Metode β-Carotene Bleaching, Journal of Tropical Pharmacy and Chemistry, 3(2), 109-119. https://doi.org/10.25026/jtpc.v3i2.97
