Studi Penggunaan Antibiotika pada Neonatus Di NICU RSAL Dr. Ramelan Surabaya
Keywords:
Neonatus, antibioticAbstract
Neonatal sepsis and nosocomial infection are the most common diagnosis of neonatal infections. Selections of antibiotics in neonatal infection should be based on type of bacteria, antibiotics dose and safety in neonates. The aim of this study was to explored type of antibiotics used in Neonatal Intensive Care Unit. Researchers conducted a prospective study of antibiotics used at Dr. Ramelan Navy Hospital neonatal intensive care unit Surabaya. From November 26th 2007 to January 26th 2008, 94 patients (5 preterm neonates and 89 term neonates) were included in this study. Demographic data, antibiotics used, relevant medical histories, laboratory data was recorded prospectively at the wards. Charts for all cases were reviewed. Early antibiotic use was defined as therapy within 72 hours of life. The most frequently used empiric antibiotic regimens were ampicillin sulbactam with gentamicin (60.2%), ampicillin sulbactam (30.1%), ceftriaxone (6.5%), ampicillin sulbactam with amikacin (1.1%), ampicillin sulbactam with ceftriaxone (1.1%), gentamicin with ceftriaxone (1.1%). Late antibiotic events also occurred in neonates. Fourty eight point four percent of late antibiotics events were used of ceftriaxone. Antibiotics are prescribed appropriately but earlier discontinuation or switches, which may be complicated either by the inability to confirm causative organism or patient’s condition that showed no improvement, should be practiced.
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