Uji Aktivitas Trakeospasmolitik Ekstrak Etanol Centella asiatica (L.) Urb. pada Organ Terpisah Trakea Marmut untuk Melihat Efek Antiasma
DOI:
https://doi.org/10.30872/j.trop.pharm.chem.v4i2.106Keywords:
Centella asiatica, spasmolytic, trachea isolated organAbstract
Asthma is a chronic inflammatory airway disease characterized by the occurrence of reversible hyperesponsif and constriction of the airways. Asthma is still a major health problem in the world. The provision of anti-asthma drugs is treatment of the disease. However, there are problems of drug side effects and problems costs incurred to purchase the drug, especially asthma is a chronic disease that requires long-term treatment. Thus it is necessary for natural based antiasthma drug development with affordable cost and fewer side effects. This study was conducted to test the potential of the ethanol extract of Centella asiatica (L.) Urb. which is traditionally used by Dayak tribe as cough medicine. This study was conducted to look at the tracheospasmolytics activity of the ethanol extract of C. asiatica on isolated organ of guinea pig trachea to see the effect of antiasthma. The results showed the extract of C. asiatica had significant tracheospasmolytics activity when compared to the negative control. Although the vE max value of C. asiatica lower than aminophylline, but the EC50 value is not much different from the aminophylline as a positive control. It is concluded that the ethanol extract of C. asiatica had the tracheospasmolytics effect based activity for antiasthma.
References
1. Alfarra HY, Omar MN. (2013). Centella asiatica: from folk remedy to the medicinal biotechnology - a state revision. International Journal of Biosciences. 3(6): 49-67.
2. Amit K, Vandana V. (2013). Medicinal properties of Acorus calamus. Journal of Drug Delivery & Therapeutics. 3(3): 143-144.
3. Bhavna D, Jyoti K. (2011). Centella asiatica: the elixir of life. International Journal of Research in Ayurveda and Pharmacy. 2(2): 431-438.
4. Chippada SC, Volluri SS, Bammidi SR, Vangalapati M. (2011). In Vitro Anti Inflammatory Activity of Methanolic Extract Of Centella asiatica BY HRBC Membrane Stabilization. Rasayan Journal of Chemistry. 4(2): 457-460.
5. Departemen Kesehatan RI. (2008). Farmakope Herbal Indonesia. Edisi Pertama. Departemen Kesehatan RI. Jakarta.
6. Ismail S, Suwasono RA, Supriyoko W, Kuswanto H, Paryono P. (2015). Laporan Penelitian Riset Eksplorasi Pengetahuan Lokal Etnomedisin dan Tumbuhan Obat di Indonesia Berbasis Komunitas di Suku Abai, Kabupaten Malinau, Propinsi Kalimantan Utara. Badan Penelitian dan Pengembangan Kesehatan. Kementerian Kesehatan RI.
7. Jamil SS, Nizami Q, Salam M. (2007). Centella asiatica (Linn.) Urban A Review. Natural Product Radiance. 6(2): 158-170.
8. Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J. (2015). Harrison’s Principles of Internal Medicine. Nineteenth Edition. 1669-1680. McGraw Hill Education. New York.
9. Katzung BG. (2009). Basic and Clinical Pharmacology. Eleventh Edition. McGraw Hill. San Fransisco.
10. Orhan IE. (2012). Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Evidence-Based Complementary and Alternative Medicine. ID 946259: 1-8.
11. Papadakis MA, McPhee SJ. (2013). Current Medical Diagnosis and Treatment. Fifty Second Edition. 243-259. McGraw Hill Lange. New York.
12. Roy DC, Barman SK, Shaik MM. (2013). Current Updates on Centella asiatica: Phytochemistry, Pharmacology and Traditional Uses. Medicinal Plant Research. 3(4): 20-36
13. The Plant List. (2013). Version 1.1. http://www.theplantlist.org
14. Vogel HG, Vogel WH. (1997). Drug discovery and evaluation: pharmacological assays. Chapter D: Respiratory activity: Spasmolytic activity in isolated guinea pig trachea. 184-185. Springer-Verlag. Berlin.
15. World Health Organization. (2013). Factsheets: Asthma. http://www.who.int/mediacentre/factsheets/fs307/en/. Diakses tanggal 29 Maret 2017.
16. World Health Organization. (1999). WHO Monographs On Selected Medicinal Plants. Volume 1. 77-85. World Health Organization. Geneva.
