Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle

Authors

  • Nelly Tagnin Nkuete Centre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-Cameroon Author
  • Sandra Leila Nnanga Centre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-Cameroon Author
  • Stephanie Tamdem Guetchueng Centre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-Cameroon Author
  • Nga Nnanga Centre of Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants studies, Ministry of Scientific Research and Innovation, P.O.Box: 130033 Yaounde-Cameroon Author
  • Joseph Ngoupayo Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon Author

DOI:

https://doi.org/10.30872/j.trop.pharm.chem.v6i1.221

Keywords:

Essential oil, Zingiber officinale, antifungal, ointments

Abstract

The increase incidence of fungal infections, the resistance of fungal strains to existing drugs and the toxicity assimilated to long term usage of antifungal drugs as prompted the search of new alternative from natural source. In this study we have evaluated the antifungal properties of the essential oil of the rhizome of Z. officinale, a plant known for its various biological properties and used in food industry as spice. An antifungal ointment with Z. officinale essential oil as active principle was also formulated and its antifungal properties evaluated. GC/MS analysis identified Zingiberene (22.36%), 1.8-cineole (15.54%), geranial (11.91%), camphene (11.09%) and geraniol (8.75%) as the main constituents of Z. officinale essential oil obtained by hydrodistillation. The oil showed a significant antifungal activity against clinical isolate of Candida krusei with MIC 800 ppm by microdilution method. The formulated ointment containing 10 % glycerol, 60 % vaseline, 8 % hydrosol, 20% lanolin and 2% Zingiber officinale essential oil (Formule E1) was found to follow pharmaceutical standards according to European Pharmacopeia and also showed good antifungal properties

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Published

2022-06-30

Issue

Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.

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Articles

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Copyright (c) 2022 Nelly Tagnin Nkuete, Sandra Leila Nnanga, Stephanie Tamdem Guetchueng, Nga Nnanga, Joseph Ngoupayo (Author)

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How to Cite

Formulation and Evaluation of an Antifungal Ointment Containing Zingiber officinale Roscoe (Zingiberaceae) Essential Oil as Active Principle. (2022). Journal of Tropical Pharmacy and Chemistry , 6(1), 38-48. https://doi.org/10.30872/j.trop.pharm.chem.v6i1.221