Test Of Anti-Acne Activity In Gel Peel Off Mask Preparation Of Papaya Leaf (Carica Papaya L.) Extract On Rabbit Backs Induced With Propionibacterium Acnes Bacteria

M. Wahyu  Ariawan; Windu Aria Renita; Muh. Deni Kurniawan; Fendy Prasetyawan

doi:10.30872/jtpc.v10i1.351

Authors

M. Wahyu Ariawan Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author
Windu Aria Renita Program Studi Farmasi S1, Sekolah Tinggi Ilmu Kesehatan Adila, Bandar Lampung Author
Muh. Deni Kurniawan Program Studi S1 Farmasi, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia Author https://orcid.org/0000-0002-9888-8743
Fendy Prasetyawan Program studi Pendidikan Profesi Apoteker, Fakultas Ilmu Kesehatan, Universitas Kadiri, Kediri, Indonesia Author

DOI:

https://doi.org/10.30872/jtpc.v10i1.351

Keywords:

(Carica papaya L.), anti-acne, propionibacterium acnes

Abstract

Acne involves inflammation and Propionibacterium acnes infection. Papaya (Carica papaya L.) leaves, containing antibacterial karpain alkaloids and anti-inflammatory flavonoids, offer potential treatment. This study aimed to formulate and evaluate papaya leaf extract peel-off gel masks for anti-acne efficacy on P. acnes-induced rabbits. Extracts were obtained via maceration using 96% ethanol. Formulations containing 5%, 10%, and 15% extract were compared against clindamycin (positive control) and a negative control. Evaluations included physical quality (organoleptic, pH, viscosity, drying time, spreadability, adhesion), irritation, and antibacterial efficacy tests. Results indicated the 15% formulation was optimal, demonstrating homogeneity, pH 5-6, spreadability of 5 cm, drying time of 17 minutes, viscosity of 3167 cps, and adhesion of 6.22 seconds, without causing irritation. In vivo observations confirmed that the 15% concentration effectively accelerated acne healing and dried pus. Thus, papaya leaf extract peel-off masks exhibit significant anti-acne activity.

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