Evaluasi Penggunaan Antibiotika Berdasarkan Kontraindikasi, Efek Samping, dan Interaksi Obat pada Pasien Rawat Inap dengan Infeksi Saluran Pernapasan Bawah Di Rumah Sakit Panti Rapih Yogyakarta Periode Januari-Juni 2005

Abstract

The non-TBC lower respiratory infection is a kind of infection that can attack bronchus, bronchioles and lung, the clinical manifestation can chronicle and severe. Generally the caused in children is virus and bacteria while in adult is bacteria, which is using antibiotics in medical attention. The purpose of research is to find out the infection pattern and the kind of antibiotics and to evaluate the using antibiotics based on effectivity. The non-experimental research that was form in a retrospective survey was done through medical record of patient with the lower respiratory infection in the time limit of January-June 2005 in Panti Rapih Hospital. The using of antibiotics was surveyed from medical record then analyzed using quantitative descriptive and presented in percentage. The results obtained showed that the contraindications and adverse reactions of drugs are not found, the incidence of drug interactions by 22 (16%) of 137 cases and of 29 types of antibiotics are used there are 7 species (24%) of potential antibiotic drug interactions. Several cases of potential interactions occurs not show clinical manifestations in patients. To avoid unwanted adverse reactions serum creatinine should be monitored especially in the use of aminoglycoside antibiotics group.