Formulasi Pasta Gigi Berbahan Aktif Ekstrak Daun Sirih Hitam sebagai Antimikroba Penyebab Radang Gusi (Gingivitis) dan Gigi Berlubang (Caries)

Abstract

This study aims to obtain a formula toothpaste preparations with active ingredient is extracts of black betel leaf which effectively kills microbes cause inflammation of the gums (gingivitis) and tooth perforated (caries). The active ingredient is obtained by performing maceration followed by fractionation of the extract. Test of antimicrobial activity against microorganisms Streptococcus mutans & Candida albicans using the diffusion method, which will get an effective concentration to be used for toothpaste formulations with active ingredient is black betel leaf. Then continued with the test and evaluation of the effectiveness of the final dosage form of toothpaste preparations. Obtained from the test concentration of 20% n-hexane extract fraction of black betel leaf have the greatest antimicrobial power against Streptococcus mutans and Candida albicans. And after optimization of the base, obtained the good mass forming of toothpaste with base PGA (Pulvis Gummi Arabica) at concentration of 30%.