Karakteristik dan Stabilitas Sediaan Gel Mulut Berbahan Aktif Ekstrak Daun Sirih Hitam Berbasis Hydroxy Ethyl Cellulose (HEC)
Keywords:
antimicrobials, mouth gel, black betel, gingivitis, cavitiesAbstract
This study aimed to obtain mouth gel formula ​​from extract of black betel leaves which effectively kill microbes that cause inflammation of the gums (gingivitis) and tooth decay (caries). The mouth gel formulation ​​from black betel leaves extract has been made by various concentrate of Hydroxy Ethyl Cellulose (HEC) as a mucoadhesive polymer. The optimized mouth gel base determine by evaluation the physical which includes organoleptic, viscosity, pH, the spreadability, and consistency after 16 days storage. The evaluation test was done with pH 7.21 (which lowest) - 7.78 (the highest). The spreadability after 16 days storage of 50 grams for formula 1, formula 2, formula 3 each is 11.33 cm, 5.60 cm, and 4.70 cm. The consistency of the mouth gel formulation ​​from black betel leaves extract on formula 1, formula 2, and formula 3 are no changes occurred up to 16 days of storage. The viscosity obtained after 16 days of storage for formula 1, formula 2, and formula 3 respectively are 4.30 dpas, 37 dpas, and 80 dpas. The result showed that formula 2 has better formulation.
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