The Effectiveness of the Antiinfamation Combination Gel of Okra Fruit (Abelmoschus esculentus) Extracts and Shallots Extract (Allium cepa L.)
DOI:
https://doi.org/10.30872/j.trop.pharm.chem.v5i1.30Keywords:
Anti-Inflammatory, Gel, Okra, Shallots, Cuts WoundAbstract
Wound is a condition that is the destruction of the unity or network components, which are specifically found the substance of tissue damaged or lost, either damage the continuity of the skin, mucous membranes and bones or other organs. Wound healing is a very complex process involving many cells. The process of wound healing is portrayed as occurs in biological surgical wound occurred. Several phases of wound healing are: the process of inflammation (inflammatory), the process of cell multiplication (proliferation) and cell maturation process (maturase). Okra is a plant that allegedly came from Southeast Asia. Okra has grown in many countries in almost all over the world. In the UK okra known as the Lady's Finger, in India it is called by the name of Bhindi while the United States called Gumbo. In Indonesia, this plant also has a local name that is Rabamea (Bima), Coffee Java (Java), Arabian Coffee (Sulawesi), Hoinu (Southeast Sulawesi), but better known by the name of okra. This study aims to determine the effective concentration and determine the length of time of wound healing using a combination gel okra fruit extract (Abelmoschus esculentus) And shallots (Allium cepa L.) as an anti-inflammatory against cuts in male white rats (Sprague -Dawley) with a length of observation for 9 days. This study uses Betadine® ointment as a positive control. The results showed the combination of fruit extract gel okra 6% and shallots 2% contained in the formula 3 most effective as an anti-inflammatory against cuts in male rats by administration for 6 days.
References
1] Abdassah, M., Formulasi Ekstrak Daun Sukun (Artocarpus Altilis Parkins Fosberg) Dengan Basis Gel Sebagai Antiinflamasi. Fakultas Farmasi Universitas Padjajaran. Jurnal Farmasi Indonesia Vol.4 No.4. 2009.
[2] Departemen Kesehatan RI. Cara Pembuatan Simplisia. Jakarta: Departemen Kesehatan RI. 2013.
[3] Farmakope Indonesia. Edisi V. Jakarta. 2014.
[4] Jaelani. Khasiat Bawang Merah. Yogyakarta: Kanisius. 2007.
[5] Materia Medika Indonesia.Jilid VI. Jakarta: Departemen Kesehatan RI. 2000.
[6] Erfandi, E. Evolusi Manajemen Luka. Jakarta. Penerbit CV. Trans Info Media. 2013.
[7] Hakiem,M,R,L. Efektivitas Ekstrak Etanol Bawang Merah (Allium cepa var. Aggregatum L.) sebagai Penyembuh Luka pada Tikus Jantan (Sprague-Dawley). Universitas Pakuan, Bogor. 2014.
[8] Hanani, E. Analisis Fitokimia. ECG. Jakarta. 2016.
[9] Hasibuan, L. Y., Soedjana, H. & Bisono., Luka. In R. Sjamsuhidajat et al., eds. Buku Ajar Ilmu Bedah Sjamsuhidajat-De Jong. Jakarta: EGC, PP. 2010.
[10] Kumar, D. S.; a review on: Abelmoschus esculentus (okra). International reasearch journal of pharmaceutical and applied sciences, 129-132. 2013.
[11] Kumar. Okra (Abelmoschus spp.) in West and Central Africa: potential and progress on its improvement. Africana Journal of Agricultural Research Vol. 5(25), pp. 3590-3598. 2010.
[12] Mirhansyah A, Vebry A, dan Arsyik I. Formulasi Dan Optimasi Basis Gel HPMC (HidroxyPropyl Methyl Cellulose) Dengan Berbagai Variasi Konsentrasi. Fakultas Farmasi Universitas Mulawarman. 2015.
[13] Naibaho, O. H., Yamlean, P. V. Y., dan Wiyono, W., Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci Yang Dibuat Infeksi Staphyloococcus aureus, Jurnal Ilmiah Farmasi, Vol. 2 No. 02. 2013.
[14] Rathod, H., dan Dhuti Metha, A Review on Pharmaceutical Gel. International Journal of Pharmaceutical Sciences. 2015.
[15] Rizky, Rahmah Fauzia., Siti Pandan Wangi, dan Imas Sulastri. Uji Efektivitas Antiinflamasi Salep Ekstrak Rimpang Kencur (Kaempferia galanga L) Terhadap Luka Sayat Pada Tikus Jantan. Cirebon : Jurnal Sains dan Ilmu Farmasi. 2017.
[16] Somantri. Pengertian Luka dan faktor yang mempengaruhi Penyembuhan Luka. Jakarta : binacipta. 2007.
[17] Sulistyaningsih, DR. Analisis Varian Rancangan Faktorial Dua Faktor RAL dengan Metode AMMI. Program studi Matematika, Universitas Diponegoro. 2010.
[18] Trisna, S. D. Pengaruh Pemberian Salep Ekstrak Buah Okra (Abelmoschus esculentus) Secara Topikal Terhadap Kecepatan Kesembuhan Luka Bakar Tikus (Rattus Norvegicus) Sebagai Hewan Model. Fakultas Kedokteran Hewan Universitas Airlangga, Surabaya. 2017.
[19] Yuliati, K.S. Efek Antiinflamasi Ekstrak Etanol Kulit Kacang Tanah (Arachis hypogea L.) Pada Tikus Putih Jantan Galur Wistar yang Diinduksi Karagenin. Skripsi. Surakarta: Fakultas Farmasi Muhammadiyah Surakarta. 2010
