Efektivitas Krim Ekstrak Metanol Batang Dan Daun Pacar Air (Impatiens balsamina L.) terhadap Bakteri Propionibacterium acnes
Keywords:
Antiacne, Impatiens balsamina L., stems and leaves extract, Propionibacterium acnesAbstract
Colonization of Propionibacterium acnes is one of factors that causes acne vulgaris. The present study was conducted to evaluate antiacne effect from cream of methanolic extract from stems and leaves of Impatiens balsamina L. towards Propionibacterium acnes, concentration that gives greatest antiacne effect and to evaluate physical and chemical properties of creams. Simplicia were extracted using soxhlet technique and methanol as solvent. Extract then formulated in cream in three variations of concentration as following 10%(F1), 15%(F2) and 20%(F3). The determination of antiacne effect was done using disc diffusion method. Evaluation of physical and chemical properties of those creams includes organoleptic examination, spreadability, adhesion and pH testing. Determination results showed the diameter of inhibition zone from F1, F2 and F3 were 8,37±2,205; 10,78±2,551; and 17,42±3,029 mm respectively. Analysis results showed that cream of F3 gave significantly greatest antiacne effect compared to F1 and F2 (p<0,05), and not significantly different to the positive control (p>0,05). The evaluation of creams showed that they had homogenous texture, nongreasy, easily washed, spreadability of 10,18±0,285 to 11,55±0,687 cm2, adhesion force of 33,299±2,821 to 60±0 minutes, and pH of 6,07±0,058 to 6,37±0,115, this showed that creams have good physical and chemical properties.
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