Efektivitas Antihiperurisemia Ekstrak Etanol Daun Seledri (EEDS) pada Tikus Induksi Kalium Oksonat

Abstract

Celery (Apium graveolens Linn) is a plant that contains phytochemicals like alkaloids, flavonoids, saponins, and tannins. This study aims to prove the effectiveness of the ethanol extract of celery leaf in lowering uric acid levels in white male rats and determine the dose of celery leaf extract which is effective in lowering uric acid levels in male rats. Celery leaf extract prepared by maceration with 96% of ethanol. The design of the study is a randomized block design. Data were analyzed by using statistical test Analysis of Variance (ANOVA) at a significant level 95% and were using 30 male rats divided into 6 treatment groups, each treatment consisted of five rats. Animals model hyperuricemia were induced by potassium oxonate 250 mg/kg except the normal group. Group I (normal) researcher provides a standard, group II (negative) suspension given Na CMC 0,5%, group III (positive) by the suspension of allopurinol 5,4 mg/kg, groups IV, V, and VI were given ethanol extract of celery leaf each with a dose of 50 mg / kg, 100 mg / kg, and 200 mg / kg. Based on the test result that further BNJ dose of ethanol extract of celery leaf is effective with 50 mg /kg.