Antimalarial Activity of Furoquinoline Alkaloids from the Leaves of Melicope moluccana
DOI:
https://doi.org/10.30872/j.trop.pharm.chem.v5i2.188Keywords:
Melicope moluccana., alkaloid, leptanoine C, haplopine-3,3´-dimethylallyl ether, antimalarialAbstract
Two furoquinoline alkaloids, leptanoine C (1) and haplopine-3,3´-dimethylallyl ether (2) were isolated from the leaves of Melicope moluccana. The chemical structure of both compounds was determined based on spectroscopic data, including UV, IR, HR-ESI-MS, 1D, and 2D NMR spectral data. The antimalarial activity of compounds 1-2 against Plasmodium falciparum 3D7 showing their IC50 values are 0.18 ppm and 2.28 µg/mL, respectively.
References
[1] Al-Rehaily, A.J., Ahmad, M.S., Muhammad, I., Al-Thukair, A.A., Perzanowski H.P., 2003. Furoquinoline alkaloids from Teclea nobilis, Phytochem., 64:1405-1411.
[3] Chen, J.J., Chang, Y.L., Teng, C.M., Su, C.C., Chen, I.S., 2002. Quinoline alkaloids and anti-platelet aggregation constituents from the leaves of Melicope semecarpifolia, Planta Med., 68, 790-793.
[3] Kassim, N.K., Rahmani, M., Ismail, A., Sukari, M.A., Ee, G.C.L., Nasir, N.M., Awang, K., 2013. Antioxidant activity-guided separation of coumarins and lignan from Melicope glabra (Rutaceae), Food. Chem., 139, 87-92.
[4] Kamperdick, C., Van, N.H., Sung, T.V., Adam, G., 1997. Benzopyran from Melicope ptelefolia leaves, Phytochem., 45, 1049-1056.
[5] Nakashima, K.I., Oyama, M., Ito, T., Witono, J.R., Darnaedi, D., Tanaka, T., Murata, J., Linuma, M., 2012. Novel zierane- and guaiane-type sesquiterpenes from the root of Melicope denhamii, Chem Biodivers., 9, 2195-2202.
[6] Nakashima, K., Oyama, M., Ito, T., Witono, J.R., Darnaedi, D., Tanaka, T., Murata, T., Iinuma M., 2011. Melicodenines A and B, novel Diels-Alder type adduct isolated from Melicope denhamii, Tetrahedron. Lett., 52, 4694-4696.
[7] Saputri, R.D., Tjahjandarie, T.S., Tanjung M., 2018. Meliglabrin, a new flavonol derivative from the leaves of Melicope glabra (Blume) T.G. Hartley, Nat Prod Sci,. 24:155-158.
[8] Saputri, R.D., Tjahjandarie, T.S., Tanjung M., 2019. Alkaloid furokuinolin dan asam sinamat ter-O-geranilasi dari kulit batang Melicope hookeri T.G. Hartley, J. Sains dan Kesehatan,. 2:1-7.
[9] Sichaem, J., Jirasirichote, A., Sapasuntikul, K., Khumkratok, S., Sawasde, P., Do, T.M.L., Tip-pyang S., 2003. New furoquinoline alkaloids from the leaves of Evodia lepta, Fitoterapia., 92:270-273.
[10] Tanjung, M; Fitriatii, F.F.; Saputri, D.S;. Tjahjandarie, T.S., 2016. Antimalarial and antioxidant of isoprenylated coumarins from the stem bark of Mesua borneensis L., J Biol Active Prod from Nature. 6, 95-100.
[11] Tanjung, M., Saputri, R.D., Wahjoedi, R.A., Tjahjandarie, T.S., 2017. 4-Methoxy-3-(3-methylbut-2-en-1-yl)-7-((3-methylbut-2-en-1-yl)oxy) quinolin-2(1H)-one from Melicope moluccana T.G. Hartley, Molbank, 1-5, https://www.mdpi.com/1422-8599/2017/2/M939
[12] Tjahjandarie, T.S., Tanjung, M.., 2015. Lead compound antimalaria dan antioksidan senyawa alkaloid, flavonoid dan kumarin dari Limonia accidisima L., Laporan Akhir Penelitian Unggulan Perguruan Tinggi, Universitas Airlangga. 1-45.
