Formulasi Tablet Nanopartikel Ekstrak Terstandar Daun Pulai (Alstonia scholaris (L). R. BR) sebagai Antidiabetes

Abstract

Pulai leaves (Alstonia scholaris (L). R. BR) is one of plants which has an antidiabetic effect. Extraction was carried by maceration kinetic with 70% ethanol and the resulting extract was concentrated by rotary evaporator to obtain a thick extract and was then changed into nanoparticles using ionic gelation method. The dried nanoparticles were formulated into tablet with direct compression method using 35% avicel PH 102.  Phytochemical screening showed both extract and nanoparticles contains alkaloid, flavonoid, saponins, tannins, steroid/triterpenoids, coumarins, quinones and essential oils. The evaluation of nanoparticles demonstrated particle size of 186.93 nm, zeta potential of -68.85 mV and spherical shape of dried particles. The evaluation tablets showed an average weight of 501.8 mg and disintegration time of 13.26 minutes. Based on the result of activity of α-glucosidase inhibition in vitro, the persentage (%) of inhibition of the extract, the nanoparticles and the tablets at concentrations of 225 mg/mL are 92.09, 85.90, and 75.83%, respectively while acarbose and quercetin showed 95.21% and 89.67 % of inhibition, respectively. It could be concluded that the tablets of nanoparticles containing extract show an antidiabetic effect.