Formulation of Chia Seed Oil (Salvia hispanica) Nanoemulgel as An Antioxidant

Zulhaerana Bahar; Chatrian Dienta; Onny Ziasti Fricilli; Hanggara Arifian; Viriyanata  Wijaya; Wisnu Cahyo Prabowo

doi:10.30872/jtpc.v10i1.371

Authors

Zulhaerana Bahar Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Chatrian Dienta Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Onny Ziasti Fricilli Clinical Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Hanggara Arifian Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Viriyanata Wijaya Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Wisnu Cahyo Prabowo Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jtpc.v10i1.371

Keywords:

Antioxidant, chia seed oil, DPPH, Nanoemulgel, topical formulation

Abstract

Chia seed oil (Salvia hispanica) contains bioactive compounds, including tocopherols and phenolics, which exhibit antioxidant properties against free radicals. This study aimed to evaluate the antioxidant activity of chia seed oil, determine the optimal nanoemulsion formulation based on physical characteristics and antioxidant activity, and develop a nanoemulgel preparation. Antioxidant activity was assessed using the DPPH method. Nanoemulsion optimization was performed by varying concentrations of the surfactant Cremophor RH 40 and cosurfactant PEG 400. The best formulation (Formula 1) consisted of Cremophor RH 40 (80%), PEG 400 (10%), and chia seed oil (5%). The selected nanoemulsion was incorporated into a nanoemulgel containing 30% nanoemulsion and 70% gel base composed of Carbopol (0.5%), DMDM hydantoin (0.5%), and propylene glycol (5%). The nanoemulgel was evaluated for organoleptic properties, pH, viscosity, homogeneity, spreadability, adhesiveness, emulsion type, stability, and antioxidant activity. Results demonstrated that the formulation possessed good and stable physical characteristics, with strong antioxidant activity (IC₅₀ = 22.10 ppm). These findings indicate its potential for development as a natural-based pharmaceutical and cosmetic product.

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