Formulation Of a Transdermal Patch Containing Pigeon Pea (Cajanus cajan L.) Extract As An Antioxidant Agent

mayang chairunnisa mayang chairunnisa; Abdul Rahim Abdul Rahim; Muhammad Taufiqurrahman Muhammad Taufiqurrahman

doi:10.30872/jtpc.v9i1.286

Authors

mayang chairunnisa mayang chairunnisa Faculty of Pharmacy Mulawarman University Author
Abdul Rahim, M. Farm. Study Program of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia Author
Muhammad Taufiqurrahman Muhammad Taufiqurrahman Study Program of Pharmacy, STIKES Dirgahayu, Samarinda, Indonesia Author

DOI:

https://doi.org/10.30872/jtpc.v9i1.286

Keywords:

pigeon pea, transdermal patch, antioxidant

Abstract

Pigeon pea (Cajanus cajan L.) is an indigenous Indonesian plant known not only as a food source but also for its high antioxidant content. This study aimed to develop a transdermal patch containing C. cajan extract and evaluate its physical properties and antioxidant activity. The extract was obtained through maceration using 96% ethanol and incorporated into patch formulations with varying concentrations of HPMC (10–20%) and PVP (10–20%). The optimal physical characteristics were observed in the formulation containing 20% HPMC and 10% PVP (F1). This base was then combined with the extract at concentrations of 10%, 15%, and 20%, followed by antioxidant testing using the DPPH method. Results showed increased antioxidant activity with higher extract concentrations, with IC₅₀ values of F1: 160.87 ppm (weak), F2: 137.09 ppm (moderate), and F3: 96.17 ppm (strong). Formula 3 demonstrated the best performance, combining good physical properties with strong antioxidant activity.

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