Mekanisme Aksi α-Mangostin Dari Garcinia tetranda Pierre Terhadap P.Falciparum Secara In Vitro
Keywords:
α- Mangostin, G. tetranda, P. falciparum, globin accumulationAbstract
Development stage of parasite resistance assay and the Globin accumulation using SDS-PAGE Method has been done to parasite P. falciparum by giving α-mangostin from G. tetranda. α-Mangostin cause delays in the development stage of the parasite P. falciparum from stage schizont to stage trofozoit and cause parasite death after 48 hour. Swelling of the parasite of abnormal parasite food vacuole occurred after administration of α-Mangostin show from the results of SDS-PAGE.
References
Mahabusarakam, W.; Kuaha, K.; Wialirat, W.; & Taylor, W.C. 2006, Prenylated Xanthones as Potential Antiplasmodial Substances, Planta Med2006; 72; 912-916
Ersam, T.; Santosa, M.; & Widyawaruyanti, A. 2008, Kajian Bioaktivitas Dan Mekanisme Aksi Antimalaria Dari Senyawa Santon Pada Tumbuhan Wadung (Garcinia Tetranda Pierre), Laporan Akhir Penelitian HPTP, LPPM-ITS; Surabaya
Sherman, I.W. 1998,Malaria, Parasite Biology, Pathogenesis and Protection, American Society for Microbiology Press; Washington, D.C., USA
Saxena, S.; Pant, N.; Jain, D.C.; & Bhakuni, R.S. 2003, Antimalarial Agents from Plant Sources, Review Articles, Current ScienceVol. 85 No. 9, November 10, hal 1314-1326
Rosenthal, P.J. 2002,Hydrolysis of Erythrocyte Proteins by Proteases of Malaria Parasites, Current Opinion in HematologyVol. 9, hal 140–145
Rosenthal, P.J.; Wollish, W.S.; Palmer, J.T.; & Rasnick, D. 1991,Antimalarial Effects of Peptide Inhibitors of a Plasmodium falciparumCysteine Proteinase, Journal Clinical Investigation Vol. 88, November, hal 1467-1472
Rosenthal, P.J 1995,Plasmodium falciparum: Effects of Proteinase Inhibitors on Globin Hydrolysis by Cultured Malaria Parasites, Experimental ParasitologyVol. 80, hal 272-281