Efek Pemberian α-Mangostin Dari Garcinia tetranda Pierre Terhadap Morfologi P.Falciparum
Keywords:
α- Mangostin, G. tetranda, P. falciparum, Transmission Electron microscope (TEM)Abstract
Morphological changes assay to P. falciparum from the effects of α-mangostin from G. tetranda using TEM methods has been done. This test aims to determine the effect of mangostin on P. falciparum by observing morphological ultrastructure of P. falciparum using transmission electron microscope (TEM). α-Mangostin known to cause morphological changes in ultrastructure of P.falciparum after contact with α- mangostin on the 12 and 24 hour.
References
Mahabusarakam, W.; Kuaha, K.; Wialirat, W.; & Taylor, W.C. Prenylated Xanthones As Potential Antiplasmodial Substances, Planta Med, 2006; 72; 912-916
Ersam, T.; Santosa, M.; & Widyawaruyanti, A. 2008, Kajian Bioaktivitas Dan Mekanisme Aksi Antimalaria Dari Senyawa Santon Pada Tumbuhan Wadung (Garcinia tetranda Pierre), Laporan Akhir Penelitian HPTP, LPPM-ITS; Surabaya
Sherman, I.W. 1998, Malaria, Parasite Biology, Pathogenesis and Protection, American Society for Microbiology Press; Washington, D.C., USA
Saxena, S.; Pant, N.;Jain, D.C.; & Bhakuni, R.S. 2003, Antimalarial Agents from Plant Sources, Review Articles, Current ScienceVol. 85 No. 9, November 10, hal 1314-1326
Rosenthal, P.J. 2002, Hydrolysis of Erythrocyte Proteins by Proteases of Malaria Parasites, Current Opinion in Hematology.Vol. 9, hal 140–145
Rosenthal, P.J.; Wollish, W.S.; Palmer, J.T.; & Rasnick, D. 1991, Antimalarial Effects of Peptide Inhibitors of a Plamodium falciparumCysteine Proteinase, Journal Clinical Investigation,Vol. 88, November, hal 1467-1472
Rosenthal, P.J. 1995, Plasmodium falciparum: Effects of Proteinase Inhibitors on Globin Hydrolysis by Cultured Malaria Parasites, Experimental Parasitology,Vol. 80, hal 272-281
Kuncoro, H. 2010, Efek Pemberian α-Mangostin Dan 1,3,6-Trihidroksi-7-Metoksi-2(1,1-Dimetil-Metoksi-propena)-8-Prenilsanton Terhadap Plasmodium falciparum secara in vitro, Tesis,Fakultas Farmasi Universitas Airlangga, Surabaya
