The Release of Sodium Diclofenac from Matrix Type of Transdermal Patch

Abstract

The sodium diclofenac realeased from transdermal patch of combination of ethyl cellulose (EC) N-20 nd polyvinyl pyrollidon (PVP) K-30 was investigated. In this study, matrix-type of transdermal patchntaining diclofenac sodium were prepared using polymeric combination of EC N-20  and PVP K-30 in various  ratios ( 9:1 (Formula I); 8:2 (Formula II); and 7:3 (Formula III)). The percentage of moisture content was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using fluorescence microscope and scanning electron microscope (SEM). Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05).  It can be concluded that the combination of EC N-20 and PVP K-30 at ratio 7:3 was the best choice for manufacturing transdermal patch based on physicochemical and the release profile.