Pengaruh Kadar Polietilen Glikol (PEG) 400 terhadap Pelepasan Natrium Diklofenak dari Sediaan Transdermal Patch Type Matriks
Keywords:
Pelepasan sodium diklofenak, plasticizer, matriks kombinasi dari EC N–20 and PVP K–30, polyetilen gliko 400Abstract
The sodium diclofenac realeased from transdermal patch of combination of EC N–20 and PVP K–30 with ratio 6:4 with plasticizer PEG 400 5% (formula 1), PEG 400 10% (formula 2) and PEG 400 20% (formula 3) was investigated. The percentage of moisture contents was calculated as a difference between initial and final weight with respect to final weight. The homogeneity of patch surface was determined using fluorescence microscope and scanning electron microscope (SEM). Released test using dissolution apparatus were carried out in 500 mL of phosphate buffer saline pH 7.4 ± 0.05 at temperature 37 ± 0.5°C with speed of swirl 50 rpm. Results were analyzed by statistic programmed of SPSS using one way analysis of variance with degree of believed 95% (α = 0,05), showed that that the combination of EC N–20 and PVP K–30 at ratio 6:4 with plasticizer PEG 400 5% was the best choice for manufacturing transdermal patch based on physicochemical and the release profile.
References
Chuasuwan, B.; Binjesoh, V.; Polli, J.E.; Zhang, H.; Amidon, G.L.; Junginger, H.E.; Midha, K.K.; Shah, V.P.; Stavchansky, S.; Dressman, J.B.; & Barends, D.M. 2008, Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Diclofenac Sodium and Diclofenac Potassium. Journal of Pharmaceutical Sciences, DOI 10.1002/jps.21525, p.1-14
Kandavilli, S.; Nair, V.; & Panchagnula, R. 2002, Polymers in Transdermal Drug Delivery Systems. Pharmaceutical technology, p. 62-80.
Kumar, R.; & Philip, A. 2007, Modified Transdermal Technologies: Breaking the Barriers of Drug Permeation via the Skin. Tropical Journal of Pharmaceutical Research, 6 (1), p 633-644
Nandi, I.; Bateson, M.; Bari, M.; & Joshi, H.N. 2003, Synergistic Effect of PEG-400 and Cyclodextrin to Enhance Solubility of Progesterone. AAPS PharmSciTech, 4(1), p 1-5
Rathbone, M.J.; Hadgraft, J.; & Roberts, M.S. 2002, Modified-Release Drug Delivery Technology, Marcel Dekker, Inc.; New York, Basel. p 471-498
Valenta, C.; & Auner, B.G. 2004, The Use of Polymers for Dermal and Transdermal Delivery. European Journal of Pharmaceutics and Biopharmaceutics, 58, p.279-289.
