Efek Hemostatis Ekstrak Metanol Daun Sisik Naga (Drymoglossum Piloselloides Presl.) pada Tikus Jantan (Rattus norvegicus L.)

Abstract

The research is The Hemostatic Effect of Sisik Naga Leaves (Drymoglossum Piloselloides  Presl.) Metanol Extract of Rat (Rattus norvegicus L.) has been done. This reseach’s purposes to determine the hemostatic effect, optimum dose and optimum measured time of Sisik Naga Leaves extract with bleeding time as its parameter used tail bleeding. Dose of Sisik Naga extract are 12.5 mg/kgBW, 25 mg/kgBW, and 50 mg/kgBW and NaCMC has been used as negative control, they were given twice a day in one day treatment. Tail bleeding by cutting the rat’s tail has been done on 12^th, 24^th, and 36^th hour after the treatment. The result data was analyzed with two way Analysis of Varian (Anava) and followed BNJD test. The test results showed that bleeding time of negative control NaCMC is 143.15 seconds and bleeding time of Sisik Naga leaves extract with dose 12.5 mg/kgBW on 12^th hours 82.62 second, 24^th hours 60.27 second, 36^th hours 76.36 second, dose 25 mg/kgBW on 12^th hours 65.76 second, 24^th hours 39.33 second, 36^th hours 90.02 second, and dose 50 mg/kgBW on 12^th hours 53.97 second, 24^th hours 23.82 second, 36^th hours 72.85. The best dose which optimum effect of hemostatic is 50 mg/kgBW with measured time on 24 hours after orally extract.